Crop operation in OpenCV is very simple. You should first read the image. Then the values x, y, h, w must be determined to specify the region to be cropped. You can do this using the code below. import cv2 image = cv2.imread( 'image.jpg' ) y= 10 x= 20 h= 200 w= 250 crop = image[y:y+h , x:x+w] cv2.imshow( 'Image' , crop) cv2.waitKey( 0 )